Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
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چکیده
منابع مشابه
Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially decreases Aβ42 levels. However, the effects of SGSMs in AD animals and cells expressing familial AD mu...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2016
ISSN: 1076-1551,1528-3658
DOI: 10.2119/molmed.2016.00127